Conquering oncogenic KRAS and its bypass mechanisms

Pingping Hou, Y. Alan Wang

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Aberrant activation of KRAS signaling is common in cancer, which has catalyzed heroic drug development efforts to target KRAS directly or its downstream signaling effectors. Recent works have yielded novel small molecule drugs with promising preclinical and clinical activities. Yet, no matter how a cancer is addicted to a specific target - cancer's genetic and biological plasticity fashions a variety of resistance mechanisms as a fait accompli, limiting clinical benefit of targeted interventions. Knowledge of these mechanisms may inform combination strategies to attack both oncogenic KRAS and subsequent bypass mechanisms.

Original languageEnglish (US)
Pages (from-to)5691-5709
Number of pages19
JournalTheranostics
Volume12
Issue number13
DOIs
StatePublished - 2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Keywords

  • KRAS
  • MEK
  • RAF
  • cancer
  • targeted therapy resistance

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