Continuous enteral and parenteral feeding each reduces heart rate variability but differentially influences monocyte gene expression in humans

Stephen C. Gale, Beth Ann Shanker, Susette M. Coyle, Marie A. MacOr, Chun W. Choi, Steve E. Calvano, Siobhan A. Corbett, Stephen F. Lowry

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Enteral (EN) or parenteral (PN) nutrition is used to support critically ill patients until oral feeding resumes. Enteral nutrition is assumed preferable to PN, but the differential influence on immune function is not well defined. Autonomic nervous activity is known to influence innate immune responses, and we hypothesized that EN and PN could influence both autonomic signaling and gene activation in peripheral blood monocytes (PBMs). Ten subjects (aged 18-36 years) received continuous EN or PN for 72 h. Peripheral blood monocytes were isolated from whole blood before and after continuous feeding and were analyzed for gene expression using a microarray platform. Gene expression after feeding was compared from baseline and between groups. To measure autonomic outflow, subjects also underwent heart rate variability (HRV) monitoring during feeding. Time and frequency domain HRV data were compared between groups and five orally fed subjects for changes from baseline and changes over time. During continuous EN and PN, subjects exhibited declines in both time and frequency domain HRV parameters compared with baseline and with PO subjects, indicating a loss of vagal/parasympathetic tone. However, PN feeding had a much greater influence on PBM gene expression compared with baseline than EN, including genes important to innate immunity. Continuous EN and PN are both associated with decreasing vagal tone over time, yet contribute differently to PBM gene expression, in humans. These preliminary findings support assumptions that PN imposes a systemic inflammatory risk but also imply that continuous feeding, independent of route, may impart additional risk through different mechanisms.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalShock
Volume38
Issue number3
DOIs
StatePublished - Aug 2012

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Keywords

  • Continuous nutrition
  • enteral nutrition
  • heart rate variability
  • inflammation
  • innate immunity
  • monocyte gene expression
  • parenteral nutrition

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