@inproceedings{cb4f0817b1854286a380d133503b8a87,
title = "Continuous magnetic bead based micro-immunosensing with extended incubation via spiral channel design",
abstract = "This work describes the development of a continuous flow magnetic bead based microfluidic biosensor for antigen concentration tracking. These devices will ultimately be applied to clinical applications such as for monitoring systemic inflammation during cardiac surgeries. A novel magnetic actuation scheme is used to enable autonomous on-chip serial reaction bead processing and detection. Previously reported devices used a single layer device with a straight incubation channel. A novel implementation is presented using a similar magnetic actuation scheme within multi-layer devices with spiral incubation channels. These devices offer reaction incubation times up to 40 times longer than previous designs with continuous bead motion for lower antigen concentration detection limits.",
keywords = "Immunoassay, Magnetic actuation, Microbeads, Spiral channel",
author = "Sasso, {Lawrence A.} and Zahn, {Jeffrey D.}",
year = "2009",
language = "English (US)",
isbn = "9780979806421",
series = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "728--730",
booktitle = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
note = "13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 ; Conference date: 01-11-2009 Through 05-11-2009",
}