Continuous Powder Mixing

Juan G. Osorio, Aditya U. Vanarase, Rodolfo J. Romañach, Fernando J. Muzzio

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations

Abstract

Continuous powder mixing has been the subject of much research in past few years since it offers several advantages over the conventional batch mixing methods still used in the pharmaceutical industry. These advantages include the opportunity for meaningful process analytical technologies (PAT) and modeling techniques to be implemented for automated process control leading to finished products with improved quality. With continuous manufacturing, the same equipment used for process development can often be used in manufacturing. Therefore, product scale up is eliminated or reduced, accelerating the introduction of new products to the market. The advantages also include significant reductions in equipment size and the ability for integration with other continuous processes already in use. This chapter provides an overview of continuous powder mixing and its mechanisms. It describes the theoretical and experimental characterization, modeling, and process control efforts. It also provides recommendations for future directions both in research and within industry.

Original languageEnglish (US)
Title of host publicationPharmaceutical Blending and Mixing
Publisherwiley
Pages101-127
Number of pages27
ISBN (Electronic)9781118682692
ISBN (Print)9780470710555
DOIs
StatePublished - Jan 1 2012

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Chemical Engineering(all)

Keywords

  • Batch mixing methods
  • Continuous mixing efficiency
  • Continuous powder mixing
  • Mixing performance
  • Process analytical technologies (PAT)
  • Process parameters
  • Product scale up

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