Control of Sindbis virus infection by antibody in interferon-deficient mice

Andrew P. Byrnes; Joan E. Durbin; Diane E. Griffin

doi:10.1128/JVI.74.8.3905-3908.2000

Control of Sindbis virus infection by antibody in interferon-deficient mice

Andrew P. Byrnes, Joan E. Durbin, Diane E. Griffin

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Antibodies clear Sindbis virus from infected animals through an unknown mechanism. To determine whether interferon-induced pathways are required for this clearance, we examined mice which are unable to respond to alpha/beta interferon or gamma interferon. Although extremely susceptible to infection, such mice survived and completely cleared virus if antibodies against Sindbis virus were given.

Original language	English (US)
Pages (from-to)	3905-3908
Number of pages	4
Journal	Journal of virology
Volume	74
Issue number	8
DOIs	https://doi.org/10.1128/JVI.74.8.3905-3908.2000
State	Published - 2000
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.74.8.3905-3908.2000

Cite this

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title = "Control of Sindbis virus infection by antibody in interferon-deficient mice",

abstract = "Antibodies clear Sindbis virus from infected animals through an unknown mechanism. To determine whether interferon-induced pathways are required for this clearance, we examined mice which are unable to respond to alpha/beta interferon or gamma interferon. Although extremely susceptible to infection, such mice survived and completely cleared virus if antibodies against Sindbis virus were given.",

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AB - Antibodies clear Sindbis virus from infected animals through an unknown mechanism. To determine whether interferon-induced pathways are required for this clearance, we examined mice which are unable to respond to alpha/beta interferon or gamma interferon. Although extremely susceptible to infection, such mice survived and completely cleared virus if antibodies against Sindbis virus were given.

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Control of Sindbis virus infection by antibody in interferon-deficient mice

Abstract

All Science Journal Classification (ASJC) codes

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