Control of Sindbis virus infection by antibody in interferon-deficient mice

Andrew P. Byrnes, Joan E. Durbin, Diane E. Griffin

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Antibodies clear Sindbis virus from infected animals through an unknown mechanism. To determine whether interferon-induced pathways are required for this clearance, we examined mice which are unable to respond to alpha/beta interferon or gamma interferon. Although extremely susceptible to infection, such mice survived and completely cleared virus if antibodies against Sindbis virus were given.

Original languageEnglish (US)
Pages (from-to)3905-3908
Number of pages4
JournalJournal of virology
Volume74
Issue number8
DOIs
StatePublished - 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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