Controlled release levodopa treatment of motor fluctuations in Parkinson's disease

J. L. Juncos, G. Fabbrini, M. M. Mouradian, C. Serrati, A. M. Kask, T. N. Chase

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


A controlled release preparation of levodopa-carbidopa, CR III, given every 4 hours to 17 Parkinsonian patients for up to 10 months reduced plasma drug variations and improved motor response fluctuations compared with standard levodopa-carbidopa given every 2 hours. The results support the value of pharmaceutical appooaches to the stabilisation of circulating levodopa levels in the treatment of Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)194-198
Number of pages5
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number2
StatePublished - 1987

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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