Coronary angioplasty during hospitalization for acute myocardial infarction is associated with higher 5-year survival

Abel Moreyra, A. C. Wilson, P. M. Gregory, John Kostis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To assess whether coronary angioplasty (PTCA) during hospitalization for acute myocardial infarction improves short- and long- term mortality. Background: Coronary reperfusion has been proven to lower mortality in patients with acute myocardial infarction. Although major trials of reperfusion therapy have demonstrated improved outcome, because of the restrictions of the inclusion criteria, they do not necessarily reflect clinical practice. Methods: Analysis of state-wide hospital discharge database containing records of 42,595 patients admitted in the years 1986- 87. Record linkage was performed to allow follow-up for survival. Results: Patients undergoing PTCA were younger (58 ± 11 years) than patients without this procedure (65 ± 12 years, p < 0.0001). In the PTCA group, there were more Caucasian patients and less comorbidity. Early revascularization (PTCA within 48 hours from admission) was performed in 41% of the patients. The crude 5-year survival rate was significantly higher among patients who had PTCA compared to patients who did not undergo PTCA during the index hospitalization (88% vs. 61%, p < 0.0001). Adjusted death-rate ratios (R.R.) were significantly lower for patients aged 50 and above who received PTCA (R.R. = 0.526, 50-69 years, R.R. = 0.455, 70-89 years). The reduction in death-rate ratio is observed for PTCA performed either early or late in hospitalization. Conclusion: This analysis of a state-wide database indicates that PTCA, at any time during the hospitalization for acute myocardial infarction, is associated with improved short- and long-term survival. Although selection bias is possible, the survival benefit still persists after controlling for differences in age, gender and comorbidity.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalDisease Management and Clinical Outcomes
Volume1
Issue number5
DOIs
StatePublished - Jan 1 1998

Fingerprint

Angioplasty
Hospitalization
Myocardial Infarction
Survival
Mortality
Comorbidity
Databases
Myocardial Reperfusion
State Hospitals
Selection Bias
Reperfusion
Survival Rate

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)

Cite this

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title = "Coronary angioplasty during hospitalization for acute myocardial infarction is associated with higher 5-year survival",
abstract = "Objective: To assess whether coronary angioplasty (PTCA) during hospitalization for acute myocardial infarction improves short- and long- term mortality. Background: Coronary reperfusion has been proven to lower mortality in patients with acute myocardial infarction. Although major trials of reperfusion therapy have demonstrated improved outcome, because of the restrictions of the inclusion criteria, they do not necessarily reflect clinical practice. Methods: Analysis of state-wide hospital discharge database containing records of 42,595 patients admitted in the years 1986- 87. Record linkage was performed to allow follow-up for survival. Results: Patients undergoing PTCA were younger (58 ± 11 years) than patients without this procedure (65 ± 12 years, p < 0.0001). In the PTCA group, there were more Caucasian patients and less comorbidity. Early revascularization (PTCA within 48 hours from admission) was performed in 41{\%} of the patients. The crude 5-year survival rate was significantly higher among patients who had PTCA compared to patients who did not undergo PTCA during the index hospitalization (88{\%} vs. 61{\%}, p < 0.0001). Adjusted death-rate ratios (R.R.) were significantly lower for patients aged 50 and above who received PTCA (R.R. = 0.526, 50-69 years, R.R. = 0.455, 70-89 years). The reduction in death-rate ratio is observed for PTCA performed either early or late in hospitalization. Conclusion: This analysis of a state-wide database indicates that PTCA, at any time during the hospitalization for acute myocardial infarction, is associated with improved short- and long-term survival. Although selection bias is possible, the survival benefit still persists after controlling for differences in age, gender and comorbidity.",
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Coronary angioplasty during hospitalization for acute myocardial infarction is associated with higher 5-year survival. / Moreyra, Abel; Wilson, A. C.; Gregory, P. M.; Kostis, John.

In: Disease Management and Clinical Outcomes, Vol. 1, No. 5, 01.01.1998, p. 175-180.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Coronary angioplasty during hospitalization for acute myocardial infarction is associated with higher 5-year survival

AU - Moreyra, Abel

AU - Wilson, A. C.

AU - Gregory, P. M.

AU - Kostis, John

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Objective: To assess whether coronary angioplasty (PTCA) during hospitalization for acute myocardial infarction improves short- and long- term mortality. Background: Coronary reperfusion has been proven to lower mortality in patients with acute myocardial infarction. Although major trials of reperfusion therapy have demonstrated improved outcome, because of the restrictions of the inclusion criteria, they do not necessarily reflect clinical practice. Methods: Analysis of state-wide hospital discharge database containing records of 42,595 patients admitted in the years 1986- 87. Record linkage was performed to allow follow-up for survival. Results: Patients undergoing PTCA were younger (58 ± 11 years) than patients without this procedure (65 ± 12 years, p < 0.0001). In the PTCA group, there were more Caucasian patients and less comorbidity. Early revascularization (PTCA within 48 hours from admission) was performed in 41% of the patients. The crude 5-year survival rate was significantly higher among patients who had PTCA compared to patients who did not undergo PTCA during the index hospitalization (88% vs. 61%, p < 0.0001). Adjusted death-rate ratios (R.R.) were significantly lower for patients aged 50 and above who received PTCA (R.R. = 0.526, 50-69 years, R.R. = 0.455, 70-89 years). The reduction in death-rate ratio is observed for PTCA performed either early or late in hospitalization. Conclusion: This analysis of a state-wide database indicates that PTCA, at any time during the hospitalization for acute myocardial infarction, is associated with improved short- and long-term survival. Although selection bias is possible, the survival benefit still persists after controlling for differences in age, gender and comorbidity.

AB - Objective: To assess whether coronary angioplasty (PTCA) during hospitalization for acute myocardial infarction improves short- and long- term mortality. Background: Coronary reperfusion has been proven to lower mortality in patients with acute myocardial infarction. Although major trials of reperfusion therapy have demonstrated improved outcome, because of the restrictions of the inclusion criteria, they do not necessarily reflect clinical practice. Methods: Analysis of state-wide hospital discharge database containing records of 42,595 patients admitted in the years 1986- 87. Record linkage was performed to allow follow-up for survival. Results: Patients undergoing PTCA were younger (58 ± 11 years) than patients without this procedure (65 ± 12 years, p < 0.0001). In the PTCA group, there were more Caucasian patients and less comorbidity. Early revascularization (PTCA within 48 hours from admission) was performed in 41% of the patients. The crude 5-year survival rate was significantly higher among patients who had PTCA compared to patients who did not undergo PTCA during the index hospitalization (88% vs. 61%, p < 0.0001). Adjusted death-rate ratios (R.R.) were significantly lower for patients aged 50 and above who received PTCA (R.R. = 0.526, 50-69 years, R.R. = 0.455, 70-89 years). The reduction in death-rate ratio is observed for PTCA performed either early or late in hospitalization. Conclusion: This analysis of a state-wide database indicates that PTCA, at any time during the hospitalization for acute myocardial infarction, is associated with improved short- and long-term survival. Although selection bias is possible, the survival benefit still persists after controlling for differences in age, gender and comorbidity.

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