Correction of murine β-thalassemia by gene transfer into the germ line

Frank Costantini, Kiran Chada, Jeanne Magram

Research output: Contribution to journalArticlepeer-review

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A murine β-thalassemia was corrected by the transfer of cloned β-globin genes into the mouse germ line. The cloned mouse βmaj-globin gene or the cloned human β-globin gene was introduced into mice deficient in β-globin synthesis because of a deletion of the βmaj-globin gene. Both introduced genes produced functional β-globin chains, leading to a reduction in one case, and elimination in another case, of the anemia and associated abnormalities of the red blood cells.

Original languageEnglish (US)
Pages (from-to)1192-1194
Number of pages3
Issue number4769
StatePublished - 1986

All Science Journal Classification (ASJC) codes

  • General


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