Correlates of anti-EBV EBNA1 IgA positivity among unaffected relatives from nasopharyngeal carcinoma multiplex families

C. M. Chang, K. J. Yu, W. L. Hsu, J. M. Major, J. Y. Chen, P. J. Lou, M. Y. Liu, S. R. Diehl, A. M. Goldstein, C. J. Chen, A. Hildesheim

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: To determine whether non-viral nasopharyngeal carcinoma (NPC) risk factors might be associated with (and mediated through) Epstein-Barr virus (EBV) serological responses linked to NPC risk, we evaluated predictors of risk of anti-EBNA1 IgA seropositivity and other markers among unaffected relatives from a large NPC family study in Taiwan. Methods: Multivariate logistic regression conditioned on family was used to examine the associations between sociodemographic, dietary, lifestyle, and occupational variables and risk of anti-EBV EBNA1 IgA positivity, anti-VCA IgA, and anti-DNase positivity. Results: Among 2393 unaffected relatives from 319 multiplex families, 1180 (49.3%) were anti-EBV EBNA1 IgA seropositive. None of the associations with anti-EBNA1 IgA were statistically significant, except for being 31-50 years of age (vs <30, adjusted ORs 0.51-0.57). For one or more EBV serological markers, there were suggestive associations for older age, GuangDong firm salted fish, betel use, current alcohol use, and male gender. Conclusion: Overall, we found little evidence to suggest that non-viral NPC risk factors significantly alter EBV serological patterns, suggesting that non-viral NPC risk factors act through pathways independent of EBV serological responses.

Original languageEnglish (US)
Pages (from-to)206-209
Number of pages4
JournalBritish Journal of Cancer
Issue number1
StatePublished - Jan 3 2012

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


  • DNase
  • EBNA1
  • Epstein-Barr virus
  • IgA
  • VCA
  • nasopharyngeal carcinoma

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