Correlation of cefoxitin MICs with the presence of mecA in Staphylococcus spp.

Jana M. Swenson, William B. Brasso, Mary Jane Ferraro, Dwight J. Hardy, Cynthia C. Knapp, David Lonsway, Sigrid McAllister, L. Barth Reller, Helio S. Sader, Dee Shortridge, Robert Skov, Melvin P. Weinstein, Barbara L. Zimmer, Jean B. Patel

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12 Scopus citations

Abstract

This report describes the results of an 11-laboratory study to determine if a cefoxitin broth microdilution MIC test could predict the presence of mecA in staphylococci. Using breakpoints of ≤4 μg/ml for mecA-negative and ≥6 or 8 μg/ml for mecA-positive isolates, sensitivity and specificity based on mecA or presumed mecA for Staphylococcus aureus at 18 h of incubation were 99.7 to 100% in three cation-adjusted Mueller-Hinton broths tested. For coagulase-negative strains at 24 h of incubation, breakpoints of ≤2 μg/ml for mecA-negative and ≥4 μg/ml for mecA-positive isolates gave sensitivity and specificity of 94 to 99% and 69 to 80%, respectively.

Original languageEnglish (US)
Pages (from-to)1902-1905
Number of pages4
JournalJournal of clinical microbiology
Volume47
Issue number6
DOIs
StatePublished - Jun 2009

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

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