Correlation of quinidine absorption with disintegration and dissolution rates

Jeffrey D. Strum, John W. Ebersole, James M. Jaffe, John L. Colaizzi, Rolland I. Poust

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

The dissolution profiles of four commercial quinidine sulfate tablets were determined using the USP rotating‐basket dissolution apparatus. Substantial differences in dissolution half‐times were noted and compared to previously reported disintegration times, absorption rate constants, and times of appearance of peak serum concentrations. Rank‐order correlations were observed among all combinations of in vivo and in vitro parameters, indicating that the absorption rates of these tablets are controlled by both disintegration and dissolution.

Original languageEnglish (US)
Title of host publicationJournal of Pharmaceutical Sciences
Pages568-569
Number of pages2
Volume67
Edition4
DOIs
StatePublished - Apr 1978
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Absorption—quinidine sulfate, four commercial tablets, related to dissolution profiles
  • Cardiac depressants—quinidine sulfate, four commercial tablets, dissolution profiles determined and related to disintegration and absorption
  • Disintegration—quinidine sulfate, four commercial tablets, related to dissolution profiles
  • Dissolution—quinidine sulfate, four commercial tablets, profiles determined and related to disintegration and absorption
  • Quinidine sulfate—four commercial tablets, dissolution profiles determined and related to disintegration and absorption

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