Corticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus

Rita J. Valentino, Stephen L. Foote, Gary Aston-Jones

Research output: Contribution to journalArticle

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Corticotropin-releasing factor (CRF) administered intraventricularly (0.5 nmol) was found to increase the discharge rates of locus coeruleus (LC) neurons in anesthetized rats. A similar effect on discharge rate was alos observed during direct application of CRF to LC neurons by pressure microapplication. Intraventricular administration of CRF-OH, previously demonstrated to be considerably less potent in releasing ACTH, did not alter LC firing rates. These data suggest that activation of these central noradrenergic neurons may constitute an integral part of the overall 'stress response' initiated by CRF release.

Original languageEnglish (US)
Pages (from-to)363-367
Number of pages5
JournalBrain research
Issue number2
StatePublished - Jul 4 1983
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


  • corticotropin-releasing factor
  • hypothalamus
  • locus coeruleus
  • median eminence
  • norepinephrine
  • peptide hormone
  • pituitary
  • stress

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