TY - JOUR
T1 - COVID-19 controlled human infection studies
T2 - Worries about local community impact and demands for local engagement
AU - Lee, Kyungdo
AU - Eyal, Nir
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - In spring, summer and autumn 2020, one abiding argument against controlled human infection (CHI) studies of SARS-CoV-2 vaccines has been their impact on local communities. Leading scientists and bioethicists expressed concern about undue usage of local residents' direly needed scarce resources at a time of great need and even about their unintended infection. They recommended either avoiding CHI trials or engaging local communities before conducting any CHIs. Similar recommendations were not made for the alternative-standard phase III field trials of these same vaccines. We argue that the health effects of CHI studies on local residents not participating in the study tend to be smaller and more positive than those of field trials. That is all the more so now that tested vaccines are being rolled out. Whether or not local community engagement is necessary for urgent vaccine studies in the pandemic, the case for its engagement is stronger prior to field trials than prior to CHI studies.
AB - In spring, summer and autumn 2020, one abiding argument against controlled human infection (CHI) studies of SARS-CoV-2 vaccines has been their impact on local communities. Leading scientists and bioethicists expressed concern about undue usage of local residents' direly needed scarce resources at a time of great need and even about their unintended infection. They recommended either avoiding CHI trials or engaging local communities before conducting any CHIs. Similar recommendations were not made for the alternative-standard phase III field trials of these same vaccines. We argue that the health effects of CHI studies on local residents not participating in the study tend to be smaller and more positive than those of field trials. That is all the more so now that tested vaccines are being rolled out. Whether or not local community engagement is necessary for urgent vaccine studies in the pandemic, the case for its engagement is stronger prior to field trials than prior to CHI studies.
UR - https://www.scopus.com/pages/publications/85106064877
UR - https://www.scopus.com/pages/publications/85106064877#tab=citedBy
U2 - 10.1136/medethics-2021-107229
DO - 10.1136/medethics-2021-107229
M3 - Article
C2 - 33980657
AN - SCOPUS:85106064877
SN - 0306-6800
VL - 47
SP - 539
EP - 542
JO - Journal of Medical Ethics
JF - Journal of Medical Ethics
IS - 8
ER -