Creatine supplementation enhances endurance performance in trained rats

Steven K. Malin, Nancy Cotugna

Research output: Contribution to journalArticlepeer-review


Minimal evidence has shown creatine (Cr) supplementation to enhance endurance performance in either humans or rats. The purpose of this study was to examine the effects of Cr supplementation on endurance performance during high-intensity exercise in trained male rats. Endurance performance was defined as the distance run. Sixteen days of running were performed over 28 days. A cycle of 7 days consisted of 2 days of training, 1 day off, 2 days of training then 2 days off and this was repeated over a total of 28 days. Cr was administered on all 28 days. Treatment rats (n = 7) drank water containing Cr while the control rats drank water with no supplement (n = 6). The Cr group's average distance run increased significantly from baseline to exercise day 16 (baseline = 128.91 m ± 18.23 vs. exercise day 16 = 217.11m ± 18.11; p < 0.005), while the control groups did not (baseline = 137.24 m ± 10.14, exercise day 16 = 101.04 m ± 14.97; p > 0.05). Over the course of the study, the treatment group's running endurance improved by 81% compared to baseline (p < 0.001) and we conclude that Cr supplementation provided rats an increased ability to run farther demonstrating possible implications for improving endurance athletes' performances.

Original languageEnglish (US)
Pages (from-to)106-116
Number of pages11
JournalJournal of Dietary Supplements
Issue number2
StatePublished - 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics
  • Pharmacology (medical)


  • Endurance
  • High-intensity exercise
  • Metabolism
  • Supplements
  • Treadmill


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