Cross-species complementation of the indispensable Escherichia coli era gene highlights amino acid regions essential for activity

R. C. Pillutla, J. D. Sharer, P. S. Gulati, E. Wu, Y. Yamashita, C. G. Lerner, M. Inouye, P. E. March

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Era is an essential GTP binding protein in Escherichia coli. Two homologs of this protein, Sgp from Streptococcus mutans and Era from Coxiella burnetii, can substitute for the essential function of Era in E. coli. Site- specific and randomly generated Era mutants which may indicate regions of the protein that are of functional importance are described.

Original languageEnglish (US)
Pages (from-to)2194-2196
Number of pages3
JournalJournal of bacteriology
Volume177
Issue number8
DOIs
StatePublished - 1995

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

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