@article{330bb1beb0b248efaa1fba703b13acad,
title = "Cryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathies",
abstract = "Laminin polymerization is the major step in basement membranes assembly. Its failures cause laminin N-terminal domain lamininopathies including Pierson syndrome. We have employed cryo-electron microscopy to determine a 3.7 {\AA} structure of the trimeric laminin polymer node containing α1, β1 and γ1 subunits. The structure reveals the molecular basis of calcium-dependent formation of laminin lattice, and provides insights into polymerization defects manifesting in human disease.",
author = "Kulczyk, {Arkadiusz W.} and McKee, {Karen K.} and Ximo Zhang and Iwona Bizukojc and Yu, {Ying Q.} and Yurchenco, {Peter D.}",
note = "Funding Information: We thank Donald Winkelmann (Rutgers University) for careful reading of the manuscript, and Erhard Hohenester (Imperial College London) for a useful discussion and funding support of one of the cryo-EM screening sessions. We are grateful to Janette Myers and Claudia Lopez for their assistance in data collection at the PNCC. A portion of this research was supported by NIH grant U24GM129547, and performed at the PNCC at OHSU and accessed through EMSL (grid.436923.9), a DOE Office of Science User Facility sponsored by the Office of Biological and Environmental Research. This study was supported by a NIH grant R01-DK36425 to P.D.Y, a PNCC-51312 grant to A.W.K., and a start-up grant from Rutgers University to A.W.K. Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
month = dec,
doi = "10.1038/s41467-023-36077-z",
language = "English (US)",
volume = "14",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}