Crystal structure of a human TATA box-binding protein/TATA element complex

Dimitar B. Nikolov, Hua Chen, Elaine D. Halay, Alexander Hoffmann, Robert G. Roeder, Stephen K. Burley

Research output: Contribution to journalArticlepeer-review

253 Scopus citations

Abstract

The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C- terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 Å resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9-Å-resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box.

Original languageEnglish (US)
Pages (from-to)4862-4867
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume93
Issue number10
DOIs
StatePublished - May 14 1996

All Science Journal Classification (ASJC) codes

  • General

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