Abstract
Crystals of a 2:1 complex between the self-complementary DNA hexamer d(ATGCAT) and the antitumor drug actinomycin D have been grown from solutions of polyethylene glycol 400. The crystals are orthorhombic with space group P212121 and a = 95.6, b = 42.7, and c = 40.8 Å. A Patterson map calculated from preliminary diffractometer data as well as packing considerations suggest a model in which the actinomycin D is intercalated into a double-stranded DNA hexamer. There are four such complexes in the asymmetric unit.
Original language | English (US) |
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Pages (from-to) | 4714-4715 |
Number of pages | 2 |
Journal | Journal of Biological Chemistry |
Volume | 259 |
Issue number | 8 |
State | Published - 1984 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology