Crystals of a 2:1 complex between the self-complementary DNA hexamer d(ATGCAT) and the antitumor drug actinomycin D have been grown from solutions of polyethylene glycol 400. The crystals are orthorhombic with space group P212121 and a = 95.6, b = 42.7, and c = 40.8 Å. A Patterson map calculated from preliminary diffractometer data as well as packing considerations suggest a model in which the actinomycin D is intercalated into a double-stranded DNA hexamer. There are four such complexes in the asymmetric unit.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of Biological Chemistry|
|State||Published - 1984|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology