Current and Emerging Molecular Markers of Liver Diseases: A Pathogenic Perspective

Yuanxin Liang, Grace L. Guo, Lanjing Zhang

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


In the past decade, with the rapid development of molecular medicine and the application of more sophisticated methods for disease diagnosis and treatment, a number of molecular markers have become available for liver diseases. Pathogenesis-related markers are likely to be effectively discovered and rigorously validated, due to the unique biological links to diseases. The present study reviews the predominant clinical and research articles in the previous decade to provide a pathogenic perspective of current and emerging biomarkers for liver diseases, including hepatocellular neoplasms (e.g. hepatocellular carcinoma), non-neoplastic hepatocellular diseases, intrahepatic biliary diseases, and other liver diseases. Although it remains challenging to cover all markers for the diagnosis and prognosis of liver diseases, current and emerging molecular markers in clinical practice and under investigation were reviewed in a wide spectrum of liver diseases, in order to help clinicians and researchers identify liver disease markers for reference.

Original languageEnglish (US)
Pages (from-to)9-19
Number of pages11
JournalGene Expression
Issue number1
StatePublished - Sep 2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics


  • Liver
  • Marker
  • Molecular
  • Pathogenic


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