Abstract
The aim of regenerative endodontics is to replace injured or infected structures, including root and crown dentine as well as cells in the pulp-dentine complex. Two strategies, cell-homing-based and cell-based regenerative strategies, are available for this purpose. In cell-homing-based regenerative strategies, the patient’s endogenous cells undertake tissue repair/regeneration, whereas a cell-based regenerative strategy requires exogenous stem cells to achieve dental pulp regeneration. Clinically, a cell-homing-based regenerative strategy, pulp revascularisation/revitalisation, has been successfully applied in immature permanent teeth with an open apex; however, there is no evidence of new innervation, new dentine deposition or neovascularisation after the procedure. In addition, pulp revascularisation/revitalisation procedures rarely achieve an extension in root length. Although pulp revascularisation treatment cannot be considered as well-controlled tissue regeneration, this procedure has advantages compared with the traditional apexification procedure, which takes more time to establish the dentine/bone tissues at the apex. This chapter describes recent approaches for the cell-homing-based regenerative strategy and identifies the potential improvements possible in pulp revascularisation/revitalisation procedures in the clinic.
Original language | English (US) |
---|---|
Title of host publication | Clinical Approaches in Endodontic Regeneration |
Subtitle of host publication | Current and Emerging Therapeutic Perspectives |
Publisher | Springer International Publishing |
Pages | 139-159 |
Number of pages | 21 |
ISBN (Electronic) | 9783319968483 |
ISBN (Print) | 9783319968476 |
DOIs | |
State | Published - Jan 1 2018 |
All Science Journal Classification (ASJC) codes
- General Dentistry
Keywords
- Immature Permanent Teeth
- Periodontal Ligament Stem Cells (PDLSCs)
- Pulp Revascularization
- Regenerative Endodontics
- Stem Cells From Apical Papilla (SCAPs)