Current and Future Views on Cell-Homing-Based Strategies for Regenerative Endodontics

Yoshifumi Kobayashi, Emi Shimizu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The aim of regenerative endodontics is to replace injured or infected structures, including root and crown dentine as well as cells in the pulp-dentine complex. Two strategies, cell-homing-based and cell-based regenerative strategies, are available for this purpose. In cell-homing-based regenerative strategies, the patient’s endogenous cells undertake tissue repair/regeneration, whereas a cell-based regenerative strategy requires exogenous stem cells to achieve dental pulp regeneration. Clinically, a cell-homing-based regenerative strategy, pulp revascularisation/revitalisation, has been successfully applied in immature permanent teeth with an open apex; however, there is no evidence of new innervation, new dentine deposition or neovascularisation after the procedure. In addition, pulp revascularisation/revitalisation procedures rarely achieve an extension in root length. Although pulp revascularisation treatment cannot be considered as well-controlled tissue regeneration, this procedure has advantages compared with the traditional apexification procedure, which takes more time to establish the dentine/bone tissues at the apex. This chapter describes recent approaches for the cell-homing-based regenerative strategy and identifies the potential improvements possible in pulp revascularisation/revitalisation procedures in the clinic.

Original languageEnglish (US)
Title of host publicationClinical Approaches in Endodontic Regeneration
Subtitle of host publicationCurrent and Emerging Therapeutic Perspectives
PublisherSpringer International Publishing
Pages139-159
Number of pages21
ISBN (Electronic)9783319968483
ISBN (Print)9783319968476
DOIs
StatePublished - Jan 1 2018

All Science Journal Classification (ASJC) codes

  • General Dentistry

Keywords

  • Immature Permanent Teeth
  • Periodontal Ligament Stem Cells (PDLSCs)
  • Pulp Revascularization
  • Regenerative Endodontics
  • Stem Cells From Apical Papilla (SCAPs)

Fingerprint

Dive into the research topics of 'Current and Future Views on Cell-Homing-Based Strategies for Regenerative Endodontics'. Together they form a unique fingerprint.

Cite this