Current molecular diagnostics of breast cancer and the potential incorporation of microRNA

Christine K. Zoon, Elizabeth Q. Starker, Arianne M. Wilson, Michael R. Emmert-Buck, Steven K. Libutti, Michael A. Tangrea

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Although comprehensive molecular diagnostics and personalized medicine have sparked excitement among researchers and clinicians, they have yet to be fully incorporated into today's standard of care. This is despite the discovery of disease-related oncogenes, tumor-suppressor genes and protein biomarkers, as well as other biological anomalies related to cancer. Each year, new tests are released that could potentially supplement or surpass standard methods of diagnosis, including serum, protein and gene expression analyses. All of these novel approaches have shown great promise, but initial enthusiasm has diminished as difficulties in reproducibility, expense, standardization and proof of significance beyond current protocols have emerged. This review will focus on current and novel molecular diagnostic tools applied to breast cancer with special attention to the exciting new field of microRNA analysis.

Original languageEnglish (US)
Pages (from-to)455-466
Number of pages12
JournalExpert Review of Molecular Diagnostics
Issue number5
StatePublished - Jul 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics


  • Breast cancer
  • MicroRNA
  • Microarray
  • Molecular diagnostics
  • Predictive value
  • Prognostic value


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