Current therapeutic strategies for inflammation following traumatic spinal cord injury

Priyanka L. Singh, Nitin Agarwal, James C. Barrese, Robert F. Heary

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Damage from spinal cord injury occurs in two phases – the trauma of the initial mechanical insult and a secondary injury to nervous tissue spared by the primary insult. Apart from damage sustained as a result of direct trauma to the spinal cord, the post-traumatic inflammatory response contributes significantly to functional motor deficits exacerbated by the secondary injury. Attenuating the detrimental aspects of the inflammatory response is a promising strategy to potentially ameliorate the secondary injury, and promote significant functional recovery. This review details how the inflammatory component of secondary injury to the spinal cord can be treated currently and in the foreseeable future.

Original languageEnglish (US)
Pages (from-to)1812-1821
Number of pages10
JournalNeural Regeneration Research
Volume7
Issue number23
DOIs
StatePublished - Aug 15 2012

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience

Keywords

  • Acute spinal cord injury
  • Erythropoietin
  • Estrogen
  • Etanercept
  • Hypothermia
  • Inflammation
  • Neuroprotective
  • Rolipram
  • Secondary injury
  • Treatment

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