Curtailed binomial sampling procedures for clinical trials with paired data

Nira Herrmann, Ted H. Szatrowski

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The use of curtailed sampling procedures in designing clinical trials with a dichotomous response and paired data is reviewed. Tables of expected sample size savings and a simple to evaluate asymptotic formula for the expected sample size savings are presented where the sample size savings is calculated relative to the fixed sample size test. Comparisons are made among fixed sample size, curtailed, and repeated significance hypothesis testing procedures. In view of the substantial savings in sample size available under certain conditions and the accuracy of the approximating formula, it is recommended that curtailed procedures be given serious consideration in the design of clinical trials.

Original languageEnglish (US)
Pages (from-to)25-37
Number of pages13
JournalControlled Clinical Trials
Issue number1
StatePublished - Mar 1985

All Science Journal Classification (ASJC) codes

  • Pharmacology


  • Clinical trials
  • curtailed sampling
  • early stopping
  • repeated testing
  • sequential tests

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