TY - JOUR
T1 - Cutting Edge
T2 - A New Approach to Modelling Early Lung Immunity in Murine Tuberculosis
AU - Bhatt, Kamlesh
AU - Hickman, Somia Perdow
AU - Salgame, Padmini
PY - 2004/3/1
Y1 - 2004/3/1
N2 - In this study, we report a new approach that allows dissection of distinct pathways regulating induction of early adaptive immunity in response to Mycobacterium tuberculosis (Mtb). We used traceable murine dendritic cells (DCs) and macrophage populations to chart their migratory pattern in response to Mtb, and found that only DCs receiving inflammatory stimuli from Mtb up-regulated their expression of CCR7 and migrated specifically to the draining lymph nodes (LNs). Furthermore, these Mtb-modulated DCs initiated a Th1 response only in the draining LNs. Taken together, these results demonstrate that Mtb-induced modulation of DCs is critical for their migration to regional LNs and ensuing T cell priming.
AB - In this study, we report a new approach that allows dissection of distinct pathways regulating induction of early adaptive immunity in response to Mycobacterium tuberculosis (Mtb). We used traceable murine dendritic cells (DCs) and macrophage populations to chart their migratory pattern in response to Mtb, and found that only DCs receiving inflammatory stimuli from Mtb up-regulated their expression of CCR7 and migrated specifically to the draining lymph nodes (LNs). Furthermore, these Mtb-modulated DCs initiated a Th1 response only in the draining LNs. Taken together, these results demonstrate that Mtb-induced modulation of DCs is critical for their migration to regional LNs and ensuing T cell priming.
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U2 - 10.4049/jimmunol.172.5.2748
DO - 10.4049/jimmunol.172.5.2748
M3 - Article
C2 - 14978073
AN - SCOPUS:1342324771
SN - 0022-1767
VL - 172
SP - 2748
EP - 2751
JO - Journal of Immunology
JF - Journal of Immunology
IS - 5
ER -