Cytokeratin 20 confirms Merkel cell metastasis to stomach

Melissa Li, Chen Liu

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Merkel cell carcinoma (MCC) is an uncommon, aggressive neuroendocrine carcinoma of the skin. Its prognosis is poor because of involvement of regional lymph nodes and metastases to distant sites such as bone, liver, lung, and brain. Very few metastases are reported to the gastrointestinal tract. Several studies have shown the utility of cytokeratin 20 to differentiate MCC from other small round blue cell tumors, particularly those with neuroendocrine differentiation. In this case report, we present an unusual metastasis to the stomach and the utility of cytokeratin 20 immunohistochemistry to confirm MCC.

Original languageEnglish (US)
Pages (from-to)346-349
Number of pages4
JournalApplied Immunohistochemistry and Molecular Morphology
Issue number4
StatePublished - Dec 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Medical Laboratory Technology


  • Cytokeratin 20
  • Gastrointestinal tract
  • Merkel cell carcinoma
  • Metastasis

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