Cytokines across the night in chronic fatigue syndrome with and without fibromyalgia

Toru Nakamura, Stephan K. Schwander, Robert Donnelly, Felix Ortega, Fumiharu Togo, Gordon Broderick, Yoshiharu Yamamoto, Neil S. Cherniack, David Rapoport, Benjamin H. Natelson

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


The symptoms of chronic fatigue syndrome (CFS) are consistent with cytokine dysregulation. This has led to the hypothesis of immune dysregulation as the cause of this illness. To further test this hypothesis, we did repeated blood sampling for cytokines while patients and matched healthy controls slept in the sleep lab. Because no one method for assaying cytokines is acknowledged to be better than another, we assayed for protein in serum, message in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found no evidence of proinflammatory cytokine upregulation. Instead, in line with some of our earlier studies, we did find some evidence to support a role for an increase in interleukin-10, an antiinflammatory cytokine. Although the changes were small, they may contribute to the common complaint in CFS patients of disrupted sleep.

Original languageEnglish (US)
Pages (from-to)582-587
Number of pages6
JournalClinical and Vaccine Immunology
Issue number4
StatePublished - Apr 2010

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)


Dive into the research topics of 'Cytokines across the night in chronic fatigue syndrome with and without fibromyalgia'. Together they form a unique fingerprint.

Cite this