Cytoprotective mechanisms of DJ-1 against oxidative stress through modulating ERK1/2 and ASK1 signal transduction

Stephanie E. Oh, M. Maral Mouradian

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

DJ-1 is a highly conserved multifunctional protein linked to both neurodegeneration and neoplasia. Among its various activities is an antioxidant property leading to cytoprotection under oxidative stress conditions. This is associated with the ability to modulate signal transduction events that determine how the cell regulates normal processes such as growth, senescence, apoptosis, and autophagy in order to adapt to environmental stimuli and stresses. Alterations in DJ-1 expression or function can disrupt homeostatic signaling networks and initiate cascades that play a role in the pathogenesis of conditions such as Parkinson's disease and cancer. DJ-1 plays a major role in various signaling pathways. Related to its anti-oxidant properties, it mediates cell survival and proliferation by activating the extracellular signal-regulated kinase (ERK1/2) pathway and attenuates cell death signaling by inhibiting apoptosis signal-regulating kinase 1 (ASK1) activation. Here, we review the ways through which DJ-1 regulates these pathways, focusing on how its regulation of signal transduction contributes to cellular homeostasis and the pathologic states that result from their dysregulation.

Original languageEnglish (US)
Pages (from-to)211-217
Number of pages7
JournalRedox Biology
Volume14
DOIs
StatePublished - Apr 2018

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Clinical Biochemistry

Keywords

  • ASK1
  • Cell signaling
  • DJ-1
  • Daxx
  • ERK
  • JNK
  • MAPK
  • Oxidative stress
  • Signal transduction
  • Trx1
  • p38

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