d-Tocotrienol is the Most Potent Vitamin E Form in Inhibiting Prostate Cancer Cell Growth and Inhibits Prostate Carcinogenesis in Ptenp-/- Mice

Hong Wang, William Yan, Yuhai Sun, Chung S. Yang

Research output: Contribution to journalArticlepeer-review

Abstract

Vitamin E compounds, consisting of a, b, g, and d forms of tocopherols and tocotrienols, display different cancer preventive activities in experimental models. Tocotrienols may have higher potential for clinical use due to their lower effective doses in laboratory studies. However, most studies on tocotrienols have been carried out using cancer cell lines. Strong data from animal studies may encourage the use of tocotrienols for human cancer prevention research. To examine the cancer inhibitory activity of different vitamin E forms, we first investigated their inhibitory activities of different vitamin E forms in prostate cancer cell lines. We found that d-tocotrienol (dT3) was the most effective form in inhibiting cell growth at equivalent doses. Because of this in vitro potency, dT3 was further studied using prostate-specific Pten-/-(Ptenp-/-) mice. We found that 0.05% dT3 in diet reduced prostate adenocarcinoma multiplicity by 32.7%, featuring increased apoptosis and reduced cell proliferation. The inhibitory effect of 0.05% dT3 in diet was similar to that of 0.2% d-tocopherol (dT) in diet reported previously. Our further study on the dT3-induced transcriptome changes indicated that dT3 inhibited genes in blood vessel development in the prostate of Ptenp-/- mice, which was confirmed by IHC. Together, our results demonstrate that dT3 effectively inhibits the development of prostate adenocarcinoma in Ptenp-/- mice, which involves inhibition of proliferation and angiogenesis and promotion of apoptosis.

Original languageEnglish (US)
Pages (from-to)233-246
Number of pages14
JournalCancer Prevention Research
Volume15
Issue number4
DOIs
StatePublished - Apr 2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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