@article{3bbbcdc10b7e43749b80c4214517276d,
title = "Daywake, an Anti-siesta Gene Linked to a Splicing-Based Thermostat from an Adjoining Clock Gene",
abstract = "Yong and Edery identify an anti-siesta gene in Drosophila, hereinafter termed daywake, that is regulated in an unprecedented manner by splicing of the cold-enhanced dmpi8 intron from the reverse-oriented and slightly overlapping period clock gene. The dmpi8-dyw unit stimulates midday activity on days that carry less risks from heat exposure.",
keywords = "0.9 gene, Daywake, Drosophila, dmpi8 intron, juvenile hormone-binding protein, midday siesta, period clock gene, pre-mRNA splicing, sleep-wake behavior",
author = "Yong Yang and Isaac Edery",
note = "Funding Information: We are very grateful to Zhicao Zhang, who was instrumental in suggesting a possible role for 0.9 in mediating the effects of dmpi8 splicing on daytime sleep and performing some of the initial experiments. This work was supported by funding from the NIH to I.E. ( R01NS42088 and R01NS105780 ). Fly stocks obtained from the Bloomington Drosophila Stock Center ( NIH P400D018537 ) and the Vienna Drosophila Resource Center (VDRC) were used in this study. We also thank the Drosophila Genomics Resource Center (supported by NIH grant 2P40OD010949 ) for plasmids. Funding Information: We are very grateful to Zhicao Zhang, who was instrumental in suggesting a possible role for 0.9 in mediating the effects of dmpi8 splicing on daytime sleep and performing some of the initial experiments. This work was supported by funding from the NIH to I.E. (R01NS42088 and R01NS105780). Fly stocks obtained from the Bloomington Drosophila Stock Center (NIH P400D018537)and the Vienna Drosophila Resource Center (VDRC)were used in this study. We also thank the Drosophila Genomics Resource Center (supported by NIH grant 2P40OD010949)for plasmids. Y.Y. conducted all the experiments; Y.Y. and I.E. contributed to the experimental plan and wrote the paper. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = may,
day = "20",
doi = "10.1016/j.cub.2019.04.039",
language = "English (US)",
volume = "29",
pages = "1728--1734.e4",
journal = "Current Biology",
issn = "0960-9822",
publisher = "Cell Press",
number = "10",
}