Decarbonylative Phosphorylation of Carboxylic Acids via Redox-Neutral Palladium Catalysis

Chengwei Liu, Chong Lei Ji, Tongliang Zhou, Xin Hong, Michal Szostak

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

We describe the direct synthesis of organophosphorus compounds from ubiquitous aryl and vinyl carboxylic acids via decarbonylative palladium catalysis. The catalytic system shows excellent scope and tolerates a wide range of functional groups (>50 examples). The utility of this powerful methodology is highlighted in the late-stage derivatization directly exploiting the presence of the prevalent carboxylic acid functional group. DFT studies provided insight into the origin of high bond activation selectivity and P(O)-H isomerization pathway.

Original languageEnglish (US)
Pages (from-to)9256-9261
Number of pages6
JournalOrganic letters
Volume21
Issue number22
DOIs
StatePublished - Nov 15 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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