Deciphering Astroglial Dynamics and Interactions Through Multi-Scale Computational Modeling in Multiple Sclerosis Evolution

Multiple sclerosis (MS) is a neurodegenerative disease affecting millions worldwide, highlighting the complex relationship between the immune system and the central nervous system. Astrocytes are recognized as significant contributors to the disease’s pathogenesis. In this work, a biophysically realistic astrocytic model was created to investigate astrocytes' role in MS development, focusing on their impact on axonal conduction and enhanced sodium channel facilitation in demyelinated axons. Through the advancement of comprehension about the involvement of astrocytes in the pathophysiology of MS, this study explores the processes underlying the disease. The study also examines the morphology of astrocytes and its influence on cellular activity, providing insights into cell instability drivers and the interaction between morphological changes and functional modifications. This approach aims to understand the complex connections between cellular characteristics and physiological attributes, enhancing our understanding of multiple sclerosis and potentially developing groundbreaking therapies.