Decoding epigenetic cell signaling in neuronal differentiation

Mariana S. Vieira, Vânia A.M. Goulart, Ricardo C. Parreira, Onésia Cristina Oliveira-Lima, Talita Glaser, Yahaira Maria Naaldijk, Alejandra Ferrer, Vibha Harindra Savanur, Paola Alicea Reyes, Oleta Sandiford, Pranela Rameshwar, Henning Ulrich, Mauro Cunha Xavier Pinto, Rodrigo R. Resende

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Neurogenesis is the process by which new neurons are generated in the brain. Neural stem cells (NSCs) are differentiated into neurons, which are integrated into the neural network. Nowadays, pluripotent stem cells, multipotent stem cells, and induced pluripotent stem cells can be artificially differentiated into neurons utilizing several techniques. Specific transcriptional profiles from NSCs during differentiation are frequently used to approach and observe phenotype alteration and functional determination of neurons. In this context, the role of non-coding RNA, transcription factors and epigenetic changes in neuronal development and differentiation has gained importance. Epigenetic elucidation has become a field of intense research due to distinct patterns of normal conditions and different neurodegenerative disorders, which can be explored to develop new diagnostic methods or gene therapies. In this review, we discuss the complexity of transcription factors, non-coding RNAs, and extracellular vesicles that are responsible for guiding and coordinating neural development.

Original languageEnglish (US)
Pages (from-to)12-24
Number of pages13
JournalSeminars in Cell and Developmental Biology
Volume95
DOIs
StatePublished - Nov 2019

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

Keywords

  • Epigenetics
  • Neural stem cells
  • Neurogenesis
  • Non-coding RNAs

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