Decompaction of CNS myelin leads to a reduction of the conduction velocity of action potentials in optic nerve

Rafael Gutiérrez, Detlev Boison, Uwe Heinemann, Wilhelm Stoffel

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

The conduction velocity of action potentials in nerve fibres is proportional to the degree of myelination. Here we studied the influence of myelin ultrastructure on the compound action potential conduction velocity in optic nerves of the proteolipid protein (PLP)-deficient mouse model, which displays loose myelination in central fibres. We show that a myelin decompaction leads to a suboptimal conduction velocity. The significance of myelin ultrastructure for conduction of action potential in the optic nerve is discussed.

Original languageEnglish (US)
Pages (from-to)93-96
Number of pages4
JournalNeuroscience Letters
Volume195
Issue number2
DOIs
StatePublished - Aug 4 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Conduction velocity
  • Gene targeting
  • Myelin decompaction
  • Optic nerve
  • Proteolipid protein

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