Decoupling the effect of growth factors on cell motility and growth in advancing monolayers using the fischer equation

Harihara Baskaran, Karen Hamoen, Abbey Perumpanani, Jeffrey Morgan, Francois Berthiaume

Research output: Contribution to journalConference articlepeer-review

Abstract

Cell motility is an important function in wound healing and in the process leading to reepithelization and closure of the wound. The effect of epidermal growth factor (EGP) and hepatocyte growth factor (HGF) was measured on the migration speed of keratinocyte monolayers. Both EGF and HGF increased migration speed, however, EGF mediated its effect by increasing cell motility while HGF increased both cell motility and specific growth rate. The Fischer equation was a useful tool to delineate the mechanism whereby growth factors enhance wound healing.

Original languageEnglish (US)
Pages (from-to)S-80
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - 2000
Externally publishedYes
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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