Decreased DBC1 expression is associated with poor prognosis in patients with non-muscle-invasive bladder cancer

Ui Jae Shim, Il Seok Lee, Ho Won Kang, Jayoung Kim, Won Tae Kim, Isaac Yi Kim, Keun Ho Ryu, Yung Hyun Choi, Sung Kwon Moon, Yong June Kim, Seok Joong Yun, Sang Cheol Lee, Wun Jae Kim

    Research output: Contribution to journalArticlepeer-review

    8 Scopus citations


    Purpose: The deleted in bladder cancer 1 (DBC1) gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in bladder cancer (BC). It is suspected that it acts as a tumor suppressor gene, but its prognostic value remains unclear. The aim of the present study was to investigate the value of DBC1 as a prognostic marker in BC. Materials and Methods: The expression of DBC1 was determined by real-time polymer-ase chain reaction analysis in 344 patients with BC (220 non-muscle-invasive BC [NMIBC] and 124 muscle-invasive BC [MIBC]) and in 34 patients with normal bladder mucosa. The results were compared with clinicopathologic parameters, and the prognostic value of DBC1 was evaluated by Kaplan-Meier analysis and a multivariate Cox regression model. Results: DBC1 expression was significantly decreased in patients with MIBC compared with those diagnosed with NMIBC (p=0.010). Patients with aggressive tumor characteristics had lower DBC1 expression levels in NMIBC (each, p<0.05). By multivariate Cox regression analysis, low DBC1 expression was a predictor of progression to MIBC (hazard ratio, 7.104; p=0.013). Kaplan-Meier estimates revealed a significant difference in tumor recurrence, progression to MIBC, and cancer-specific survival depending on the level of DBC1 expression in NMIBC (log-rank test, each, p<0.05). Conclusions: The expression of DBC1 was associated with tumor aggressiveness, progression to MIBC, and survival in NMIBC. Our results suggest that DBC1 expression can be a useful prognostic marker for patients with NMIBC.

    Original languageEnglish (US)
    Pages (from-to)631-637
    Number of pages7
    JournalKorean Journal of Urology
    Issue number9
    StatePublished - Sep 2013

    All Science Journal Classification (ASJC) codes

    • Urology


    • Bladder cancer
    • Human DBC1 protein
    • Prognosis


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