Decreased incorporation of phosphate and amino acids into low-solubility, nuclear proteins in rapidly growing hepatomas

M. A. Lea; M. R. Koch

doi:10.1016/0020-711X(77)90077-5

Decreased incorporation of phosphate and amino acids into low-solubility, nuclear proteins in rapidly growing hepatomas

M. A. Lea, M. R. Koch

New Jersey Medical School (NJMS), Biochemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

1. 1. The incorporation of ³²P-phosphate and ³H-amino acids was studied in nuclear protein fractions of normal and neoplastic liver. 2. 2. The most marked change in hepatomas was a decreased incorporation of isotope into a low solubility fraction of non-histone proteins in rapidly growing tumors. 3. 3. The phosphate content of this fraction was lower in Morris hepatomas 9618A₂ and 7777 than host livers. 4. 4. Significant decreases were not seen in slowly growing hepatomas and regenerating rat liver.

Original language	English (US)
Pages (from-to)	565-572
Number of pages	8
Journal	International Journal of Biochemistry
Volume	8
Issue number	8
DOIs	https://doi.org/10.1016/0020-711X(77)90077-5
State	Published - 1977

All Science Journal Classification (ASJC) codes

Biochemistry

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10.1016/0020-711X(77)90077-5

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@article{e81da18015774a8e83017a1e98c565b5,

title = "Decreased incorporation of phosphate and amino acids into low-solubility, nuclear proteins in rapidly growing hepatomas",

abstract = "1. 1. The incorporation of 32P-phosphate and 3H-amino acids was studied in nuclear protein fractions of normal and neoplastic liver. 2. 2. The most marked change in hepatomas was a decreased incorporation of isotope into a low solubility fraction of non-histone proteins in rapidly growing tumors. 3. 3. The phosphate content of this fraction was lower in Morris hepatomas 9618A2 and 7777 than host livers. 4. 4. Significant decreases were not seen in slowly growing hepatomas and regenerating rat liver.",

author = "Lea, {M. A.} and Koch, {M. R.}",

note = "Funding Information: Acknowledgements-This work was supported in part by USPHS grant CA-12933 and CA-16274 from the National Institutes of Health. We are indebted to Dr. H. P. Morris for providing tumor-bearing rats from which hepatomas were transplanted in these studies. We are grateful to Ms. Connie Sheffield for secretarial assistance.",

year = "1977",

doi = "10.1016/0020-711X(77)90077-5",

language = "English (US)",

volume = "8",

pages = "565--572",

journal = "International Journal of Biochemistry",

issn = "0020-711X",

publisher = "Elsevier Limited",

number = "8",

}

TY - JOUR

T1 - Decreased incorporation of phosphate and amino acids into low-solubility, nuclear proteins in rapidly growing hepatomas

AU - Lea, M. A.

AU - Koch, M. R.

N1 - Funding Information: Acknowledgements-This work was supported in part by USPHS grant CA-12933 and CA-16274 from the National Institutes of Health. We are indebted to Dr. H. P. Morris for providing tumor-bearing rats from which hepatomas were transplanted in these studies. We are grateful to Ms. Connie Sheffield for secretarial assistance.

PY - 1977

Y1 - 1977

N2 - 1. 1. The incorporation of 32P-phosphate and 3H-amino acids was studied in nuclear protein fractions of normal and neoplastic liver. 2. 2. The most marked change in hepatomas was a decreased incorporation of isotope into a low solubility fraction of non-histone proteins in rapidly growing tumors. 3. 3. The phosphate content of this fraction was lower in Morris hepatomas 9618A2 and 7777 than host livers. 4. 4. Significant decreases were not seen in slowly growing hepatomas and regenerating rat liver.

AB - 1. 1. The incorporation of 32P-phosphate and 3H-amino acids was studied in nuclear protein fractions of normal and neoplastic liver. 2. 2. The most marked change in hepatomas was a decreased incorporation of isotope into a low solubility fraction of non-histone proteins in rapidly growing tumors. 3. 3. The phosphate content of this fraction was lower in Morris hepatomas 9618A2 and 7777 than host livers. 4. 4. Significant decreases were not seen in slowly growing hepatomas and regenerating rat liver.

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U2 - 10.1016/0020-711X(77)90077-5

DO - 10.1016/0020-711X(77)90077-5

M3 - Article

AN - SCOPUS:0017755824

SN - 0020-711X

VL - 8

SP - 565

EP - 572

JO - International Journal of Biochemistry

JF - International Journal of Biochemistry

IS - 8

ER -

Decreased incorporation of phosphate and amino acids into low-solubility, nuclear proteins in rapidly growing hepatomas

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