1. 1. The incorporation of 32P-phosphate and 3H-amino acids was studied in nuclear protein fractions of normal and neoplastic liver. 2. 2. The most marked change in hepatomas was a decreased incorporation of isotope into a low solubility fraction of non-histone proteins in rapidly growing tumors. 3. 3. The phosphate content of this fraction was lower in Morris hepatomas 9618A2 and 7777 than host livers. 4. 4. Significant decreases were not seen in slowly growing hepatomas and regenerating rat liver.
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