Decreased sensitivity of rat pups to long-lasting dopamine and serotonin depletions produced by methylamphetamine

James B. Lucot, George C. Wagner, Charles R. Schuster, Lewis S. Seiden

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Neonatal rats were administered 6-hydroxydopamine or high doses of methylamphetamine and the long-lasting effect on monoamine levels were examined. The neonatal rats were very sensitive to dopamine depletions produced by 6-hydroxydopamine. In contrast, the neonatal rats demonstrated little sensitivity to dopamine and serotonin depletions produced by methylamphetamine. Comparison of the depletions produced by these neonatal treatments with the depletions reported for adult treatments revealed that the neonatal rats were more sensitive to the 6-hydroxydopamine-induced depletions and less sensitive to the methylamphetamine-induced depletions.

Original languageEnglish (US)
Pages (from-to)181-183
Number of pages3
JournalBrain research
Volume247
Issue number1
DOIs
StatePublished - Sep 9 1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • 6-hydroxydopamine
  • dopamine depletions
  • methylamphetamine
  • neonatal rats
  • serotonin depletions

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