Decreased sensitivity of rat pups to long-lasting dopamine and serotonin depletions produced by methylamphetamine

James B. Lucot; George C. Wagner; Charles R. Schuster; Lewis S. Seiden

doi:10.1016/0006-8993(82)91047-2

Decreased sensitivity of rat pups to long-lasting dopamine and serotonin depletions produced by methylamphetamine

James B. Lucot, George C. Wagner, Charles R. Schuster, Lewis S. Seiden

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Neonatal rats were administered 6-hydroxydopamine or high doses of methylamphetamine and the long-lasting effect on monoamine levels were examined. The neonatal rats were very sensitive to dopamine depletions produced by 6-hydroxydopamine. In contrast, the neonatal rats demonstrated little sensitivity to dopamine and serotonin depletions produced by methylamphetamine. Comparison of the depletions produced by these neonatal treatments with the depletions reported for adult treatments revealed that the neonatal rats were more sensitive to the 6-hydroxydopamine-induced depletions and less sensitive to the methylamphetamine-induced depletions.

Original language	English (US)
Pages (from-to)	181-183
Number of pages	3
Journal	Brain research
Volume	247
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(82)91047-2
State	Published - Sep 9 1982
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Keywords

6-hydroxydopamine
dopamine depletions
methylamphetamine
neonatal rats
serotonin depletions

Access to Document

10.1016/0006-8993(82)91047-2

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AU - Wagner, George C.

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AU - Seiden, Lewis S.

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