Dedifferentiated liposarcoma of thigh with chondrosarcomatous dedifferentiated component.

Richard S. Yoon, Joseph Benevenia, Kathleen S. Beebe, Meera Hameed

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Liposarcomas are common soft-issue sarcomas arising predominantly in deep soft tissue and the retroperitoneum with varied mortality and recurrence rates, largely dependent on histologic type. Thought to arise de novo, liposarcomas typically are classified into 5 types based on strict morphologic characteristics: well-differentiated, dedifferentiated, myxoid, round cell, and pleomorphic. More specifically, dedifferentiated liposarcoma, a common type most prevalent in the retroperitoneum, often has 2 distinct components, a well-differentiated lipomatous component and a dedifferentiated nonlipomatous component composed of sarcomas, such as myxofibrosarcomas or other spindle-cell sarcomas. Morphology typically ranges from low- to high-grade components, most commonly exhibiting myxofibrosarcoma and malignant fibrous histiocytoma components. However, the case reported in this article is unique-the dedifferentiated component exhibited only chondrosarcomatous differentiation-and it is, to our knowledge, the first such case to be described.

Original languageEnglish (US)
Pages (from-to)E114-118
JournalAmerican journal of orthopedics (Belle Mead, N.J.)
Issue number11
StatePublished - Nov 2010

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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