Abstract
Deep brain stimulation (DBS) is used to treat the motor symptoms of Parkinson's disease patients by stimulating the subthalamic nucleus. However, optimization of DBS is still needed since the performance of the neural electrodes is limited by the body's response to the implant. This review discusses the issues with DBS, such as placement of electrodes, foreign body response, and electrode degradation. The current solutions to these technical issues include modifications to electrode material, coatings, and geometry.
| Original language | English (US) |
|---|---|
| Article number | e3179 |
| Journal | Biotechnology Progress |
| Volume | 37 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 1 2021 |
All Science Journal Classification (ASJC) codes
- Biotechnology
Keywords
- Parkinson's disease
- electrode coatings
- electrode materials
- inflammatory response
- neural electrodes