TY - JOUR
T1 - Deficient DNA binding of an apurinic/apyrimidinic DNA endonuclease activity from xeroderma pigmentosum cells
AU - Bickley, Lynn K.
AU - Lambert, Muriel W.
PY - 1988/3
Y1 - 1988/3
N2 - A chromatin-associated apurinic/apyrimidinic (AP) DNA endonuclease activity, pI 9.8, from both normal human and xeroderma pigmentosum, complementation group A (XPA), lymphoblastoid cells was examined for its ability to bind AP DNA using a filter binding assay. The endonuclease activity from normal cells produced significantly greater binding to AP DNA than to untreated DNA, but this increase in binding was not observed when the XPA endonuclease was incubated with AP DNA versus untreated DNA. These results indicate that the XPA AP endonuclease activity is deficient in its ability to bind to AP DNA.
AB - A chromatin-associated apurinic/apyrimidinic (AP) DNA endonuclease activity, pI 9.8, from both normal human and xeroderma pigmentosum, complementation group A (XPA), lymphoblastoid cells was examined for its ability to bind AP DNA using a filter binding assay. The endonuclease activity from normal cells produced significantly greater binding to AP DNA than to untreated DNA, but this increase in binding was not observed when the XPA endonuclease was incubated with AP DNA versus untreated DNA. These results indicate that the XPA AP endonuclease activity is deficient in its ability to bind to AP DNA.
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U2 - 10.1016/0309-1651(88)90100-2
DO - 10.1016/0309-1651(88)90100-2
M3 - Article
C2 - 2454750
AN - SCOPUS:0023971760
SN - 0309-1651
VL - 12
SP - 231
EP - 237
JO - Cell Biology International Reports
JF - Cell Biology International Reports
IS - 3
ER -