Defining the specific physiological requirements for c-Myc in T cell development

Nataki C. Douglas, Harris Jacobs, Alfred L.M. Bothwell, Adrian C. Hayday

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


c-Myc is associated with cell growth and cycling in many tissues and its deregulated expression is causally implicated in cancer, particularly lymphomagenesis. However, the contribution of c-Myc to lymphocyte development is unresolved. We show here that the formation of normal lymphocytes by c-Myc-/- cells is selectively defective. c-Myc-/- cells are inefficient, in an age-dependent manner, at populating the thymus, and subsequent thymocyte maturation is ineffective: they fail to grow and proliferate normally at the late double-negative (DN) CD4-CD8- stage. Because N-Myc expression in thymocytes usually declines at the late DN stage, these results confirm that the nonredundant contributions of Myc family members to development are related to their distinct patterns of developmental gene expression.

Original languageEnglish (US)
Pages (from-to)307-315
Number of pages9
JournalNature Immunology
Issue number4
StatePublished - Apr 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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