Background: The majority of complications following (LITT) therapy occur in the early postoperative period, with few long-term complications being reported. Case Description: Here we present 2 cases of delayed-onset cyst formation occurring more than 1 year following ablation, a previously unreported complication. In the first case, a 59-year-old female who previously underwent LITT for a radiation-induced cavernoma developed a 2-cm cystic lesion 18 months after ablation, resulting in recurrent seizures. In the second case, a 53-year-old female with a recurrent left frontal cerebral metastasis developed a large cystic lesion 30 months post ablation. Both patients required craniotomies and resection of their cystic lesions. In both cases pathology demonstrated reactive gliosis and blood vessel sclerosis. Conclusions: We hypothesize chronic gliosis following LITT therapy results in blood vessel sclerosis leading to blood-brain barrier−breakdown and delayed cyst formation. These findings support the need for long-term surveillance of patients treated with LITT.
All Science Journal Classification (ASJC) codes
- Clinical Neurology
- Cyst formation
- Long-term complications