TY - GEN
T1 - Delivery of neurotrophic factors in a silk-based nerve conduit for peripheral nerve repair
AU - Carvalho, Cristiana R.
AU - Chang, Wei
AU - Reis, Rui L.
AU - Oliveira, Joaquim M.
AU - Kohn, Joachim
N1 - Funding Information:
EU-FP7-Health-2011-collaborative project 278612, Biohybrid-Templates for peripheral nerve regeneration and PhD Scholarship (Norte-08-5369-FSE-000037). J. M. Oliveira also thanks the FCT for the funds provided under the program Investigador FCT 2012 and 2015 (IF/00423/2012 and IF/01285/2015)
Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: As a promising alternative to autologous nerve grafts, tissue-engineered conduits have been extensively studied as a technique to bridge peripheral nerve defects and guide nerve regeneration. However, the lack of neurotrophic factors in axonal retrograde transport following peripheral nerve injury is one of the factors causing the incomplete and deficient nerve regeneration and consequent incomplete functional recovery [1]. In this work, a new methodology developed by our group to produce silk conduits was used [2], allowing to manufacture novel and tunable silk-based tubular conduits, recurring to an enzymatically-crosslinked silk fibroin hydrogel. Since it has been established before that exogenous supply of neurotrophic factors support the survival of neurons [3], we have developed silk nerve conduits capable of incorporating and releasing both Nerve Growth Factor (NGF) or Glial cell-derived neurotrophic factor (GDNF).
AB - Statement of Purpose: As a promising alternative to autologous nerve grafts, tissue-engineered conduits have been extensively studied as a technique to bridge peripheral nerve defects and guide nerve regeneration. However, the lack of neurotrophic factors in axonal retrograde transport following peripheral nerve injury is one of the factors causing the incomplete and deficient nerve regeneration and consequent incomplete functional recovery [1]. In this work, a new methodology developed by our group to produce silk conduits was used [2], allowing to manufacture novel and tunable silk-based tubular conduits, recurring to an enzymatically-crosslinked silk fibroin hydrogel. Since it has been established before that exogenous supply of neurotrophic factors support the survival of neurons [3], we have developed silk nerve conduits capable of incorporating and releasing both Nerve Growth Factor (NGF) or Glial cell-derived neurotrophic factor (GDNF).
UR - http://www.scopus.com/inward/record.url?scp=85065436969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065436969&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85065436969
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 407
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -