TY - JOUR
T1 - Demographic trends and disease-specific survival in salivary acinic cell carcinoma
T2 - An analysis of 1129 cases
AU - Patel, Neal R.
AU - Sanghvi, Saurin
AU - Khan, Mohemmed N.
AU - Husain, Qasim
AU - Baredes, Soly
AU - Eloy, Jean Anderson
PY - 2014/1
Y1 - 2014/1
N2 - Objective/Hypothesis Acinic cell carcinoma (AciCC) is a rare salivary gland malignancy that most commonly arises in the parotid gland. Characteristics of AciCC are slow growth and a long clinical course. As a rare tumor, population-based studies are limited. We analyzed the incidence and survival for AciCC using a national population-based database. Study Design Retrospective analysis. Methods The United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry was utilized to calculate incidence and disease-specific survival trends for AciCC between 1973 and 2009. Patient data were stratified according to age, gender, race, grade, and extent of disease. Incidence trends were studied across the last 30 years and long-term disease-specific survival outcomes were compared across the different demographic parameters. Results A total of 1,129 cases of AciCC were identified, comprising of 672 (59.52%) females. Incidence trend analysis revealed significant changes in yearly incidence rates from 1973 to 2009 for male gender and white and "others" races. Overall 5-year survival was 97.15%, 10-year survival was 93.81%, and 20-year survival was 89.74%. Significant differences in survival outcomes were noted for extent of disease. Patients exhibiting distant metastasis displayed the worse long-term prognosis at 21.99% 20-year disease-specific survival. Hazard ratios demonstrated a significant increase in mortality in patients with poorly differentiated, undifferentiated, and metastatic disease. Conclusion Trends in incidence of AciCC are influenced by gender, race and age. Long-term survival of this rare malignant tumor is influenced by gender, grade, race, and extent of disease. Future studies need to be conducted to investigate these dynamic trends related to AciCC. Level of Evidence 2b. Laryngoscope, 124:172-178, 2014
AB - Objective/Hypothesis Acinic cell carcinoma (AciCC) is a rare salivary gland malignancy that most commonly arises in the parotid gland. Characteristics of AciCC are slow growth and a long clinical course. As a rare tumor, population-based studies are limited. We analyzed the incidence and survival for AciCC using a national population-based database. Study Design Retrospective analysis. Methods The United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry was utilized to calculate incidence and disease-specific survival trends for AciCC between 1973 and 2009. Patient data were stratified according to age, gender, race, grade, and extent of disease. Incidence trends were studied across the last 30 years and long-term disease-specific survival outcomes were compared across the different demographic parameters. Results A total of 1,129 cases of AciCC were identified, comprising of 672 (59.52%) females. Incidence trend analysis revealed significant changes in yearly incidence rates from 1973 to 2009 for male gender and white and "others" races. Overall 5-year survival was 97.15%, 10-year survival was 93.81%, and 20-year survival was 89.74%. Significant differences in survival outcomes were noted for extent of disease. Patients exhibiting distant metastasis displayed the worse long-term prognosis at 21.99% 20-year disease-specific survival. Hazard ratios demonstrated a significant increase in mortality in patients with poorly differentiated, undifferentiated, and metastatic disease. Conclusion Trends in incidence of AciCC are influenced by gender, race and age. Long-term survival of this rare malignant tumor is influenced by gender, grade, race, and extent of disease. Future studies need to be conducted to investigate these dynamic trends related to AciCC. Level of Evidence 2b. Laryngoscope, 124:172-178, 2014
KW - Acinic cell carcinoma
KW - cancer
KW - demographic
KW - disease-specific survival
KW - incidence
KW - malignancy
KW - salivary gland
UR - http://www.scopus.com/inward/record.url?scp=84895843350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84895843350&partnerID=8YFLogxK
U2 - 10.1002/lary.24231
DO - 10.1002/lary.24231
M3 - Article
C2 - 23754708
AN - SCOPUS:84895843350
SN - 0023-852X
VL - 124
SP - 172
EP - 178
JO - Laryngoscope
JF - Laryngoscope
IS - 1
ER -