Deoxygenative alkynylation of amides via C 00000000 00000000 00000000 00000000 11111111 00000000 11111111 00000000 00000000 00000000 O bond cleavage

Lan Chen; Wei Zhou; Jianwen Zhang; Yimin Ding; Michal Szostak; Chengwei Liu

doi:10.1039/d4cc02316a

Deoxygenative alkynylation of amides via C 00000000 00000000 00000000 00000000 11111111 00000000 11111111 00000000 00000000 00000000 O bond cleavage

Lan Chen
, Wei Zhou
, Jianwen Zhang
, Yimin Ding
, Michal Szostak
, Chengwei Liu

Rutgers Newark, Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A novel deoxygenative alkynylation of amides promoted by a synergistic action of a divalent rare-earth element and a transition metal has been developed. In this method, α-alkynyl substituted amines are synthesized from unactivated amides and alkynes in a single transformation. Broad substrate scope and excellent selectivity for C O cleavage has been demonstrated. This approach represents a general method for the construction of versatile α-alkynyl substituted amines from unactivated amide bonds.

Original language	English (US)
Pages (from-to)	8454-8457
Number of pages	4
Journal	Chemical Communications
Volume	60
Issue number	64
DOIs	https://doi.org/10.1039/d4cc02316a
State	Published - Jul 11 2024

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d4cc02316a

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abstract = "A novel deoxygenative alkynylation of amides promoted by a synergistic action of a divalent rare-earth element and a transition metal has been developed. In this method, α-alkynyl substituted amines are synthesized from unactivated amides and alkynes in a single transformation. Broad substrate scope and excellent selectivity for C O cleavage has been demonstrated. This approach represents a general method for the construction of versatile α-alkynyl substituted amines from unactivated amide bonds.",

author = "Lan Chen and Wei Zhou and Jianwen Zhang and Yimin Ding and Michal Szostak and Chengwei Liu",

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T1 - Deoxygenative alkynylation of amides via C 00000000 00000000 00000000 00000000 11111111 00000000 11111111 00000000 00000000 00000000 O bond cleavage

AU - Chen, Lan

AU - Zhou, Wei

AU - Zhang, Jianwen

AU - Ding, Yimin

AU - Szostak, Michal

AU - Liu, Chengwei

PY - 2024/7/11

Y1 - 2024/7/11

N2 - A novel deoxygenative alkynylation of amides promoted by a synergistic action of a divalent rare-earth element and a transition metal has been developed. In this method, α-alkynyl substituted amines are synthesized from unactivated amides and alkynes in a single transformation. Broad substrate scope and excellent selectivity for C O cleavage has been demonstrated. This approach represents a general method for the construction of versatile α-alkynyl substituted amines from unactivated amide bonds.

AB - A novel deoxygenative alkynylation of amides promoted by a synergistic action of a divalent rare-earth element and a transition metal has been developed. In this method, α-alkynyl substituted amines are synthesized from unactivated amides and alkynes in a single transformation. Broad substrate scope and excellent selectivity for C O cleavage has been demonstrated. This approach represents a general method for the construction of versatile α-alkynyl substituted amines from unactivated amide bonds.

UR - https://www.scopus.com/pages/publications/85199678712

UR - https://www.scopus.com/pages/publications/85199678712#tab=citedBy

U2 - 10.1039/d4cc02316a

DO - 10.1039/d4cc02316a

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EP - 8457

JO - Chemical Communications

JF - Chemical Communications

IS - 64

ER -

Deoxygenative alkynylation of amides via C 00000000 00000000 00000000 00000000 11111111 00000000 11111111 00000000 00000000 00000000 O bond cleavage

Abstract

All Science Journal Classification (ASJC) codes

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