Depressed responsiveness of the carotid sinus reflex in conscious newborn animals

S. F. Vatner, W. T. Manders

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The responsiveness of the carotid sinus reflex was evaluated by comparing the effects of bilateral carotid occlusion (BCO) in conscious adult dogs and puppies on measurements of arterial pressure, cardiac output, heart rate, and calculations of total peripheral resistance (TPR). In eight adult dogs, BCO increased mean arterial pressure by 57±6%, TPR by 48±5%, and heart rate by 45±15%. In puppies, BCO induced smaller increases (P<0.05) in mean arterial pressure (30±5%) and TPR (29±4%), while heart rate did not change. After elimination of opposing vagal and aortic baroreceptor reflexes, the differences in responses to BCO of mean arterial pressure and TPR between adults and newborns were even greater. Thus, the carotid baroreceptor reflex appears to be depressed in the newborn when compared with the fully developed reflex in the normal, conscious adult.

Original languageEnglish (US)
Pages (from-to)H40-H43
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume6
Issue number1
DOIs
StatePublished - 1979
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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