Depression and anxiety in Parkinson's disease: Possible effect of genetic variation in the serotonin transporter

Matthew A. Menza, Brandon Palermo, Rocco DiPaola, Jacob I. Sage, Michael H. Ricketts

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

Recently, a functional polymorphism in the promoter region of the serotonin transporter gene has been linked to anxiety. In cell culture, the short allele of this polymorphism synthesizes less serotonin transporter, resulting in a reduction of the removal of serotonin from the synaptic cleft. This pilot study examines depression and anxiety in Parkinson's disease patients as a function of the variation in this polymorphism. Thirty-two patients were genotyped and then blindly administered the Hamilton Depression and Anxiety Scales. Clinical data on the neurologic features of the disease were also gathered. Patients with the short allele of the serotonin transporter promotor scored significantly higher on both the depression and anxiety measures. There were no differences between groups for any neurologic variable. Patients with the short allele were more likely to have scores for anxiety and depression that indicated 'caseness.' This study suggests that the short allele of the serotonin transporter gene may represent a significant risk factor for the development of anxiety and depression in Parkinson's disease patients.

Original languageEnglish (US)
Pages (from-to)49-52
Number of pages4
JournalJournal of Geriatric Psychiatry and Neurology
Volume12
Issue number2
DOIs
StatePublished - 1999

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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