Depressive symptoms over the course of HIV infection before AIDS

C. G. Lyketsos, D. R. Hoover, M. Guccione, M. A. Dew, J. Wesch, E. G. Bing, G. J. Treisman

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59 Scopus citations


The objective of this study was to describe the prevalence and course of depressive symptoms before AIDS in HIV-infected homosexual men. A descriptive and comparative analysis of data from HIV-infected and -uninfected homosexual men in the Multicenter AIDS Cohort Study was performed. The Center for Epidemiologic Studies Depression Scale (CES-D) was the primary measure of depressive symptoms. The prevalence of depressive symptoms and CES-D caseness estimates in the AIDS-free HIV-infected homosexual men were stable over time. Small differences between HIV seropositive and seronegative men were detected on the CES-D and on three of its subscales. These were mostly accounted for by less hope, and by more fearfulness, insomnia, and anorexia in the seropositive cohort. We concluded that there does not appear to be an overall increase in depressive symptoms in HIV-infected homosexual men from the time of infection until prior to AIDS. However, this group of men consistently report specific depressive symptoms more often. Implications of these findings for the clinical care of HIV-infected patients is discussed.

Original languageEnglish (US)
Pages (from-to)212-219
Number of pages8
JournalSocial Psychiatry and Psychiatric Epidemiology
Issue number3-4
StatePublished - 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Health(social science)
  • Social Psychology
  • Psychiatry and Mental health

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