Design and characterization of a handheld multimodal imaging device for the assessment of oral epithelial lesions

Laura M. Higgins, Mark C. Pierce

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A compact handpiece combining high resolution fluorescence (HRF) imaging with optical coherence tomography (OCT) was developed to provide real-time assessment of oral lesions. This multimodal imaging device simultaneously captures coregistered en face images with subcellular detail alongside cross-sectional images of tissue microstructure. The HRF imaging acquires a 712 × 594 μm2 field-of-view at the sample with a spatial resolution of 3.5 μ m. The OCT images were acquired to a depth of 1.5 mm with axial and lateral resolutions of 9.3 and 8.0 μm, respectively. HRF and OCT images are simultaneously displayed at 25 fps. The handheld device was used to image a healthy volunteer, demonstrating the potential for in vivo assessment of the epithelial surface for dysplastic and neoplastic changes at the cellular level, while simultaneously evaluating submucosal involvement. We anticipate potential applications in real-time assessment of oral lesions for improved surveillance and surgical guidance.

Original languageEnglish (US)
Article number086004
JournalJournal of Biomedical Optics
Volume19
Issue number8
DOIs
StatePublished - Aug 2014

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Keywords

  • high resolution fluorescence
  • optical coherence tomography
  • oral cavity

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