Design and implementation of a constant-current pulsed iontophoretic stimulation device

C. A. Zakzewski; J. K.J. Li; D. W. Amory; J. C. Jensen; E. Kalatzis-Manolakis

doi:10.1007/BF02523856

Design and implementation of a constant-current pulsed iontophoretic stimulation device

C. A. Zakzewski, J. K.J. Li, D. W. Amory, J. C. Jensen, E. Kalatzis-Manolakis

School of Engineering, Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The circuit design and implementation of a flexible iontophoretic device, which synthesizes and emits several iontophoretic waveforms, are discussed. A circuit diagram of the constant-current iontophoretic device is presented. It is shown that DC, monophasic rectangular pulse, and monophasic trapezoidal constant-current iontophoresis offer a safe and effective means of enhanced transdermal drug delivery. Autoregulated control of blood pressure using simple feedback techniques is not possible with iontophoretic delivery of the angiotensin-converting enzyme (ACE) inhibitor.

Original language	English (US)
Pages (from-to)	484-488
Number of pages	5
Journal	Medical and Biological Engineering and Computing
Volume	34
Issue number	6
DOIs	https://doi.org/10.1007/BF02523856
State	Published - Nov 1996

All Science Journal Classification (ASJC) codes

Biomedical Engineering
Computer Science Applications

Keywords

Angiotensin-converting enzyme inhibitor
Captopril
Drug administration routes
Hypertension
Lonotophoresis
Rabbits

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10.1007/BF02523856

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title = "Design and implementation of a constant-current pulsed iontophoretic stimulation device",

abstract = "The circuit design and implementation of a flexible iontophoretic device, which synthesizes and emits several iontophoretic waveforms, are discussed. A circuit diagram of the constant-current iontophoretic device is presented. It is shown that DC, monophasic rectangular pulse, and monophasic trapezoidal constant-current iontophoresis offer a safe and effective means of enhanced transdermal drug delivery. Autoregulated control of blood pressure using simple feedback techniques is not possible with iontophoretic delivery of the angiotensin-converting enzyme (ACE) inhibitor.",

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T1 - Design and implementation of a constant-current pulsed iontophoretic stimulation device

AU - Zakzewski, C. A.

AU - Li, J. K.J.

AU - Amory, D. W.

AU - Jensen, J. C.

AU - Kalatzis-Manolakis, E.

PY - 1996/11

Y1 - 1996/11

N2 - The circuit design and implementation of a flexible iontophoretic device, which synthesizes and emits several iontophoretic waveforms, are discussed. A circuit diagram of the constant-current iontophoretic device is presented. It is shown that DC, monophasic rectangular pulse, and monophasic trapezoidal constant-current iontophoresis offer a safe and effective means of enhanced transdermal drug delivery. Autoregulated control of blood pressure using simple feedback techniques is not possible with iontophoretic delivery of the angiotensin-converting enzyme (ACE) inhibitor.

AB - The circuit design and implementation of a flexible iontophoretic device, which synthesizes and emits several iontophoretic waveforms, are discussed. A circuit diagram of the constant-current iontophoretic device is presented. It is shown that DC, monophasic rectangular pulse, and monophasic trapezoidal constant-current iontophoresis offer a safe and effective means of enhanced transdermal drug delivery. Autoregulated control of blood pressure using simple feedback techniques is not possible with iontophoretic delivery of the angiotensin-converting enzyme (ACE) inhibitor.

KW - Angiotensin-converting enzyme inhibitor

KW - Captopril

KW - Drug administration routes

KW - Hypertension

KW - Lonotophoresis

KW - Rabbits

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Design and implementation of a constant-current pulsed iontophoretic stimulation device

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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