Design and implementation of a constant-current pulsed iontophoretic stimulation device

C. A. Zakzewski, J. K.J. Li, D. W. Amory, J. C. Jensen, E. Kalatzis-Manolakis

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The circuit design and implementation of a flexible iontophoretic device, which synthesizes and emits several iontophoretic waveforms, are discussed. A circuit diagram of the constant-current iontophoretic device is presented. It is shown that DC, monophasic rectangular pulse, and monophasic trapezoidal constant-current iontophoresis offer a safe and effective means of enhanced transdermal drug delivery. Autoregulated control of blood pressure using simple feedback techniques is not possible with iontophoretic delivery of the angiotensin-converting enzyme (ACE) inhibitor.

Original languageEnglish (US)
Pages (from-to)484-488
Number of pages5
JournalMedical and Biological Engineering and Computing
Issue number6
StatePublished - Nov 1996

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Computer Science Applications


  • Angiotensin-converting enzyme inhibitor
  • Captopril
  • Drug administration routes
  • Hypertension
  • Lonotophoresis
  • Rabbits


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